antiangiogenesis相关论文
Dual-Functional c(RGDyK)-Decorated Pluronic Micelles for Antiangiogenesis and Drug Resistant Tumor T
Dual-function drug delivery system was developed by decorated c(RGDyK) peptide with Pluronic micelles (c(RGDyK)-FP-DP) t......
Background: Currently in vogue, the main antitumor therapy is an antiangiogenic therapy, that widely thought could lead ......
The complicated pathogenesis plays a key role in the sustained growth of solid tumor.Conventional single therapeutic age......
Anticancer effects of Gekko ethanol extract In human hepatocellular carcinoma HepG2 cells and In H22
Aim: To explore the anticancer effects and underlying mechanism of Gekko ethanol extract (GEE) in vitro and in vivo.Meth......
Construction of uPAR-Targeted Heterostructures for Efficient Photothermal-Chemotherapy against Cervi
Rational design and construction of theranostic nanomedicines based on clinical characteristics of cervical cancer is an......
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Inhibition of tumor growth in xenografted nude mice with adenovirus-mediated endostatin gene compari
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Efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorect
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在肿瘤靶向治疗研究中,抗血管生成治疗是近十年来的一个研究热点.目前已有许多血管生成抑制剂应用于临床试验中.色素上皮衍生因子(......
Inhibition of tumor growth in xenografted nude mice with adenovirus-mediated endostatin gene compari
Background Inhibition of tumor growth by endostatin has been shown to be an effective strategy in cancer therapy in mice......
Efficacy and safety of first-line chemotherapy plus bevacizumab in patients with metastatic colorect
Background What benefits and toxicities patients acquire from the use of bevacizumab combined with first-line chemothera......
Vascular endothelial growth factor (VEGF) binding to its tyrosine kinase receptors (KDR/FLK1, Flt-1) induces angiogenesi......
Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense o
Objective: To observe the inhibition of intracranial glioma tumorigenesis by vascular endothelial growth factor (VEGF) a......
色素上皮细胞衍生因子(pigment epithelium-derived factor,PEDF)是由视网膜色素上皮细胞分泌的一种蛋白质,属于丝氨酸蛋白酶抑制......
目的 观察纳米金对裸鼠H22肝癌血管生成及肝癌生长的抑制作用.方法 运用原子力显微镜(AFM)观察纳米金与血管内皮生长因子165(VEGF1......
Hypoxia is a common phenomenon in solid tumors. Resistance of hypoxic tumor cells to radiation is a significant reason o......
Inhibition of tumor growth in xenografted nude mice with adenovirus-mediated endostatin gene compari
Background Inhibition of tumor growth by endostatin has been shown to be an effective strategy in cancer therapy in mice......
Objective: To develop a novel adenoviral vector system, which combines the advantages of the antiangiogenic gene therapy......
Inhibitory Effects of TNP-470 in Combination with BCNU on Tumor Growth of Human Glioblastoma Xenogra
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根据国家癌症中心发布的最新癌症报告,胃癌是我国发病率第二位、死亡率第三位的恶性肿瘤。胃癌多起病隐匿,约35%的患者在就诊时已......
目的：研究藤梨根对人脐静脉血管内皮细胞（HUVECS）增殖作用的影响，从抑制血管生成途径探讨藤梨根抗肿瘤的作用机制。方法：运用MTT法，观察......
目的：研究放射线联合重组人血管内皮生长抑素（Endostatin）对HNE1鼻咽癌移植瘤生长、转移的抑制作用。方法：应用裸鼠建立HNE1移植瘤模型......
脚剖嚣张索（1-7）[angiotensin-（1-7），Ang-（1-7）]是朦．血割酬黜（renin．angiotensinsystem，R．AS）中新近发现的一种内源性七肽氨基酸肽类激素，通过与......
Inhibitory Effects of TNP-470 in Combination with BCNU on Tumor Growth of Human Glioblastoma Xenogra
This study investigated the effect of TNP-470 in combination with carmustine (BCNU) on the growth of subcutaneously impl......
目的:构建人血管抑素原核分泌型融合表达载体pEZZ18-As,诱导表达融合蛋白.方法:从人肝组织中提取总RNA,用RT-PCR的方法获得血管抑......
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为了研究重组人纤溶酶原Kringle1-5(K1-5)的抗血管生成活性及其对内皮细胞增殖的影响,通过PCR扩增人纤溶酶原K1-5 cDNA,定向克隆于......
[摘要]目的：研究血管抑制基因治疗对兔耳增生性瘢痕的病理学影响。方法：复制兔耳增生性瘢痕，待创面上皮化后10天瘢痕组织局部多点注射......
目的观察重组人血管内皮抑素（恩度）联合顺铂治疗恶性胸腔、腹腔积液的临床效果。方法将82例恶性胸、腹腔积液患者引流排净积液后，42例......
目的探讨四种不同品系葡萄提取物对人脐静脉内皮细胞(HUVEC)形成新生血管及分泌基质金属蛋白酶-2(MMP-2)的抑制作用.方法新鲜葡萄......
目的研究人重组内皮抑素（recombinant human endostatin）（简称内皮抑素）对人肝癌单独及联合化疗的作用。方法在体外单独应用内皮抑素或......
AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatoce......
AIM: To demonstrate that administering heparanase inhibitor PI-88 at 160 mg/d is safe and promising in reducing hepatoce......
介绍了肿瘤血管生成的过程、特点、调控因素及其与肿瘤转移的关系，简要综述了抗血管生成的临床应用。......
目的研究血管抑制剂Ad—METH1对兔耳增生性瘢痕组织及其VEGF表达的影响，探讨其作用机制。方法选取10只健康的日本大耳白兔，将兔耳制......
目的研究重组腺病毒介导的鼠内皮抑素（mEndostatin）基因对子宫内膜异位症的抑制作用。方法构建携带mEn-dostatin基因的重组腺病毒载......
【目的】构建人肿瘤抑素（Tumstatin）功能区Tum-5原核融合表达载体pET42a-Tum5。【方法】根据人Tumstatin基因序列以及大肠杆菌密码子......
目的应用斑马鱼模型研究小金胶囊（麝香、木鳖子、制草乌等）的抗肿瘤作用。方法荧光标记的人乳腺癌细胞（michigan cancer foundation-7......
目的:探讨新生血管特异性结合肽GX1二聚体对胃癌新生血管生成的影响。方法:化学合成GX1二聚体、GX1单体、对照肽二聚体,CCK-8实验......
Canstatin为Ⅳ型胶原α2链双链片段的内源性蛋白, 作为特异性的血管生成抑制因子,能抑制内皮细胞(EC)增生、迁移并有抑制EC形成血......
目的探讨靶向血管治疗脑胶质瘤的研究进展。方法分别从该方法的依据、具体方法、肿瘤血管抑制剂的开发、抗血管基因治疗、优越性以......
Suppression of intracranial glioma tumorigenesis with vascular endothelial growth factor antisense o
Objective: To observe the inhibition of intracranial glioma tumorigenesis by vascular endothelial growth factor (VEGF) a......
目的:克隆人内皮抑素(endostatin)基因并对其表达产物进行抗肿瘤活性研究.方法:从人肝cDNA文库中获得人endostatin基因,构建入载体......
色素上皮细胞衍生因子(pigment epithelium-derived factor,PEDF)是由视网膜色素上皮细胞分泌的一种蛋白质,属于丝氨酸蛋白酶抑制......
晚期肺癌脑转移发生率高,预后差。近年来,随着肺癌总体治疗的发展,为晚期肺癌脑转移提供了更多的治疗手段和期待。目前的临床研究......
本研究旨在观察血小板因子4cDNA全长或其17-70片段转染多发性骨髓瘤细胞株对其在动物体内生长的影响。构建含有人血小板因子4cDNA......
目的研究并获得重组人血管抑素(angiostatin),探讨其临床应用价值.方法采用逆转录-聚合酶链式反应(RT-PCR)方法,从人胚胎肝细胞中......
肿瘤的生物学行为依赖血管生成,故抗血管生成治疗成为肿瘤综合治疗的研究热点。血管生成在子宫内膜癌的生长、浸润、转移中也发挥......
